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Effective delivery of drugs is a major problem in today’s healthcare. At a fundamental level, the challenge of drug delivery reflects the fact that the drug distribution in the body is limited by body’s natural metabolic processes and transport barriers. These biological barriers, while serving an important purpose of regulating body’s metabolic functions, limit the drug dose that ultimately reaches the target site. Accordingly, many drugs fail to reach their full therapeutic potential. Our research aims at developing a fundamental understanding of body’s key biological barriers such as skin, intestinal epithelium and the immune system, and utilizing this understanding to develop novel means to negotiate these barriers to deliver drugs. Our research has led to the understanding of how transport properties of biological barriers can be modulated to deliver drugs in effective ways for the treatment of diseases such as diabetes and cancer, among others. I will present an overview of the lessons learned from our exploration of these biological barriers.
Samir Mitragotri is the Hiller Professor of Bioengineering and Wyss Professor of Biologically Inspired Engineering at Harvard University. He is an elected member of the National Academy of Engineering, National Academy of Medicine and National Academy of Inventors. He is a foreign member of Indian National Academy of Engineering. He is also an elected fellow of AAAS, CRS, BMES, AIMBE, and AAPS. He received BS in Chemical Engineering from the Institute of Chemical Technology, India and PhD in Chemical Engineering from the Massachusetts Institute of Technology. He is the Editor-in-Chief of AIChE’s and SBE’s journal Bioengineering and Translational Medicine.
Thursday, October 10, 2019 at 1:00pm to 2:00pm
Pharmacy Building (PHR), 4.114
2409 UNIVERSITY AVE , Austin, Texas 78712