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Javier O. Morales, Ph.D. is an Associate Professor in the Department of Pharmaceutical Science and Technology at the School of Chemical and Pharmaceutical Sciences of the University of Chile and an Associate Researcher in the Advanced Center for Chronic Diseases (ACCDiS). Dr. Morales research lines are directed towards the development of novel drug delivery systems for the delivery of peptide and protein drugs and poorly water-soluble drugs (BCS class II and IV). The strategies employed for this purpose include the use of delivery systems for alternative routes of administration, and nanoencapsulation of peptides and proteins for targeting and tailoring drug release and bioresponsive delivery systems. His research in alternative delivery routes of administration are aimed at enabling buccal absorption of biologics using nanostructured polymeric films as dosage forms. More recently, his research in buccal delivery of biologics delves in manufacturing polymeric films loaded by 2D inkjet printing of solutions and nanosuspensions as well as 3D printing of dosage forms. His current research in nanoparticulate delivery systems is aimed at achieving formulations for cardiovascular diseases, gastroretentive delivery systems, developing brain targeted delivery systems, as well as establishing the fundamental variables controlling the formation of nanoparticles by coacervation and antisolvent nanoprecipitation.
This talk will highlight the research of the Drug Delivery Lab at the University of Chile in their investigations towards enabling poorly water soluble drugs and protein and peptide drugs and improve their biopharmaceutical properties for enhanced potential therapeutic outcomes.Buccal drug delivery of proteins and peptides remains a challenge addressedand continues to be developed by the team. Inkjet printing of films for buccal delivery of insulin and other peptide/protein drugs will be presented. More recently, new research in the group is expanding the inkjet printing strategy towards poorly water soluble and poorly permeable drugs that would benefit from enhanced bioavailability achieved through this route.The bioresponsive strategy for drug delivery will be presented in the absorption followed by targeting and the covalent gastroretentive conceptscurrently addressed in the group. Other investigations include remotely triggerable drug release systems and CNS-targeted nanocarrier development.
Thursday, October 31, 2019 at 1:00pm to 2:00pm
Pharmacy Building (PHR), 4.114
2409 UNIVERSITY AVE , Austin, Texas 78712